Fondaparinux konutai paura
Te ahua: he ma ki te paura ma
Paerewa: USP
Te kaha o te tuku: 50kg ia marama
Te Ora: E rua tau
Te utu: T / T, LC, DA ranei
Wā Tukunga: Reri Stock
Origin: China
Te tuku: DHL, FedEx, TNT, EMS, Ma te Moana, Ma te Air
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Kupu Whakataki hua
Ka tukuna e matou te Fondaparinux sodium API
He tohunga taatau ki te whakakakahu i te kounga kairangi Fondaparinux konutai paura, he rongoa e whakamahia ana hei awhina me te rongoa i nga toto toto. I ahu mai a maatau hua mai i nga kaihanga pono me te whakahaere i nga tikanga whakahaere kounga hei whakarite i tona ma me te whai hua. He anticoagulant pono, he kaha te whakamahi i roto i nga mahi rongoa mo tona whaihua ki te aukati i te thrombosis oro hohonu me te embolism pulmonary. Ahakoa he kamupene rongoa koe, he whare horoi, he taiwhanga haumanu ranei, ka taea e matou te hoatu ki a koe me te kaha whakawhirinaki o Fondaparinux konutai ki te whakatutuki i o hiahia. korero mai ki a maatau ki te ako atu mo o maatau hua me o ratonga.
He aha te Fondaparinux sodium?
Fondaparinux konutai paura he momo rongoa antithrombotic hou i whakaaetia e te FDA mo te maimoatanga me te aukati i te taera o te toto totika me te toto totoka, whai muri i te heparin me te heparin taumaha ngota iti. Ko te konutai sulfonamide he taonga tauwehe Xa kua whakahiatohia, e mahi ana ma te hono whanui ki te tauwehe A, me te whakanui ake i te paanga kino o te AITn ki runga i nga mea Xa kua whakakorikoria ma te 30 nga wa, na reira ka wetewete i te urupare wairere coagulation me te aukati i te hua thrombin me te ahunga whakamua o te thrombus. Karekau te konutai sulfonamide e pa ana ki te thrombin, engari ka taea te aukati i te hua o te thrombin ma te aukati i te take Xa. E kiia ana ko ia 1 papaki o te aukati tauwehe Xa ka taea te awhina i te 50 moti o te hua thrombin.
Pārongo Basic
Ingoa Hua: Fondaparinux sodium
CAS:114870-03-0
MF:C31H43N3O49S8.10Na
MW:1728.08
EINECS: 686-283-7
Nama MDL:MFCD06794972
Maamaa: 99%+
Origin: China
Taupānga: Anticoagulant
Wā Tukunga: taonga
Te tātai hanganga:
Ira whakarewa:>209 ° C (dec.)
Te hurihanga motuhake: D23+48 ° (c=0.61 ki te wai)
Wairewa: whakarewa ki te wai
Whakapūtātanga Hangarau:
|
Te nama take |
Whakapūtātanga |
Tuhinga |
|
ahua |
He paura ma, he ma ranei |
paura White |
|
Tāutunga |
IR: Ko te tuāwhiorangi pōkākā o te tauira whakamātautau kia rite |
Whakauru |
|
HPLC: Te wa pupuri o te tihi maapono i whiwhi mai i te whakamatautau |
Whakauru |
|
|
matū e pā ana |
poke A NMT 0.8% |
0.23 orau |
|
poke B NMT 0.6% |
0.11 orau |
|
|
Tetahi poke kore i tohua NMT 0.3% |
0.13 orau |
|
|
Tapeke poke NMT 2.0% |
0.5 orau |
|
|
Water |
≤15.0% |
0.63 orau |
|
Te konutai |
11.5% ~ 15.0% |
13.2 orau |
|
Te pūkawa ngāwha kore utu |
≤0.30% |
0.14 orau |
|
pūhaumāota |
≤1.0% |
0.21 orau |
|
Ngā whakarewa taiao |
Te whakatutuki i nga whakaritenga ICH |
Whakauru |
|
anga matou |
98.0% ~ 102.0% |
99.23 orau |
Mōkī: 10g; 50g; 100g
Nga tikanga rokiroki: Puritia ki te waahi pouri, te hau koretake, 2-8°C
Mōhiohio Haumaru
Kupu Whakatupato: Whakatupato
Tauākī mōrearea: H332 Te Whakangohanga He Kino
Nga tohutohu aukati:
Nga tikanga aukati:
——P261 A ape i te manawa puehu/paowa/ hau/paowa/kohu/rehu.
——Ka taea anake te whakamahi i te P271 ki waho, ki te whai hau pai ranei.
Whakautu aitua:
——P304+P340 Mēnā ka whakangoatia ohoreretia: Whakawhitihia te tangata ki tētahi wāhi hau hou, kia pai te noho manawa.
——P312 Mena kei te ngoikore koe, waea atu ki te pokapu whakamomori/taakuta
Nga morearea ki te hauora: Ka kino ma te whakangohanga.
Ara waihanga
Ko te tikanga whakarite ko nga waahanga e whai ake nei:
1) I te aroaro o nga whakarewa waro me nga whakakorikori, ka honoa te monosaccharide E-3 me te tetrasaccharide DCBA-2 kia whiwhi pentasaccharide EDCBA-1.
2) I raro i te aroaro o nga whakarewa pararopi me nga turanga pararopi, ka whakamarohia te pentasaccharide EDCBA-1 kia whiwhi ai te pentasaccharide EDCBA-2; Ko te whakarewa waro e whakaahuatia ana he ranunga o te kotahi, neke atu ranei o te dichloromethane, methanol, ethanol, me te tetrahydrofuran; Ko te turanga parakore he kotahi, he ranunga ranei o te konutai waiwai me te konutai waikawa; Ko te pāmahana tauhohenga he 0-50 ℃.
3) Te sulfonation o te pentasaccharide EDCBA-2 me te sulfur trioxide trimethylamine, te hydrogenation catalytic, me te sulfonation me te sulfur trioxide pyridine ki te whiwhi konutai fondaparinux.
Te mahi huawhenua
Ko te paura konutai Fondaparinux he mea whakahiatohia me te aukati whiriwhiringa o te whakakorikori tauwehe X. Ko tana mahi antithrombotic ko te hua o te whakakore i te tauwehenga Xa i waenga i te antithrombin III (ATIII). Na roto i te herenga maataki ki te ATIII, ka whakanuia (tata ki te 300 nga wa) te mahi whakaheke taketake o ATIII ki te tauwehe Xa. Ko te paheketanga i runga i te tauwehe Xa ka whakararu i te tauhohenga cascade coagulation me te aukati i te hanga o te thrombin me te whakanuia o te thrombus. Kaore e taea e ia te whakakore i te thrombin (whakaoho take II) karekau he paanga ki nga platelets. I te horopeta o te 2.5mg, karekau te sulfamethoxazole e pa ki nga whakamatautau whakamohoatanga o te waa penei i te wa whakahoahohia te wahanga thromboplastin (aPTT), te wa whakakorikori whakahohe (ACT), te wa prothrombin plasma ranei (PT) / tauwehenga paerewa o te ao (INR), kaore hoki e pa. te wa toto, te mahi fibrinolytic ranei. Heoi ano, he purongo ohorere onge mo te pikinga o te horopeta 2.5mg ki te aPTT. Kaore e whiti ki te plasma mai i nga turoro me te heparin thrombocytopenia.
He aha te tono o te konutai Fondaparinux
Ko te konutai Fondaparinux e whakamahia ana i roto i nga turoro e mahi ana i nga mahi orthopedic nui i roto i nga waewae o raro, penei i te pakaru o te hipoki, te pokanga turi nui, te whakakapi hipoki ranei, hei aukati i te puta mai o nga kaupapa thromboembolism venous. Mo te maimoatanga o te angina e kore e pumau, te waahanga ST kore ranei e piki ake ana i nga turoro o te mate ohotata (<120 meneti Te Puka Matū) maimoatanga invasive (PCI) kaore he tohu. Ka whakamahia mo te maimoatanga o te waahanga ST teitei o nga turoro o te mate myocardial infarction e whakamahi ana i te thrombolysis, kaore ranei i te tuatahi ka whiwhi i etahi atu momo rongoa reperfusion.
Nga rauemi tohutoro
Ma Ying, Zhao Baolian, Wang Xuanqi, aha atu He rangahau whakatairite mo te whaihua me te haumaru o te werohanga konutai sulfamethoxazole me te werohanga konupūmā heparin iti ngota i roto i te wawaotanga coronary percutaneous i roto i nga turoro me te mate kore ST elevation acute coronary syndrome. CNKI, 2017
Tang Yongqun, Huang Xiwei, Hu Zheng He tikanga rapu mo nga katote sulfate kore utu i roto i te werohanga konutai sulfamethoxazole
Tang Yongqun, Huang Xiwei, Hu Zheng He tikanga whakaputa o te werohanga konutai sulfamethoxazole
Zhang Xiaoyan, Wang Lijuan He rangahau haumanu mo te huinga o te werohanga Danhong me te konutai sulfamethoxazole i roto i te maimoatanga o te embolism pulmonary. CNKI, 2018
Haisike: Tono mo te Whakangao o te Waohanga Sodium Sulfonate. Te Tirohanga Hiko o te Maakete, 2014
Nga korero whakapä
Hei whakarāpopototanga, hei kaiwhakarato o Fondaparinux konutai paura , Xi'an Yihui he nui te wheako whakaputa me te matauranga hangarau, nga hua o te kounga teitei, te kaha whakaputa ngawari, me te ratonga kaihoko kounga, ka taea te tautoko me te ratonga pai ki nga kaihoko.
ki te hiahia koe, pls pai ki te whakapiri mai ki a maatau i nga wa katoa. ka whakautu wawe matou ki a koe.
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